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Sale Sharks fly-half Charlie Hodgson is sidelined by a hamstring injury while full-back Josh Lewsey, centre Mike Tindall, scrum-half Matt Dawson, hooker
Steve Thompson, prop Julian White and lock Danny Grewcock - who boast more than
300 test caps between them - have all been dropped.
All bar Lewsey are relegated to the bench, while there are starts for Tom
Voyce, Stuart Abbott, Harry Ellis, Andrew Sheridan, Lee Mears and Simon
Shaw.
Leicester's Andy Goode takes over from Hodgson, and
will make his first Six Nations start. Newcastle fly-half Dave Walder, meanwhile, has been drafted on to the bench
as cover for Goode.
England:
15 Tom Voyce (London Wasps) 14 Mark Cueto (Sale
Sharks) 13 Jamie Noon (Newcastle Falcons) 12 Stuart Abbott (London Wasps) 11
Ben Cohen (Northampton Saints) 10 Andy Goode (Leicester Tigers) 9 Harry Ellis
(Leicester Tigers) 8 Martin Corry (Leicester Tigers) 7 Lewis Moody (Leicester
Tigers) 6 Joe Worsley (London Wasps) 5 Simon Shaw (London Wasps) 4 Steve
Borthwick (Bath) 3 Matt Stevens (Bath) 2 Lee Mears (Bath) 1 Andy Sheridan
(Sale Sharks).
Replacements: 16 Steve Thompson (Northampton
Saints) 17 Julian White (Leicester Tigers) 18 Danny Grewcock (Bath) 19
Lawrence Dallaglio (London Wasps) 20 Matt Dawson (London Wasps) 21 Dave Walder
(Newcastle Falcons) 22 Mike Tindall (Gloucester)
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