Doran Jones impressed with his performance in the win over the Irish Wolfhounds last Saturday evening and the prop has retained his place in the front row.
Lamb meanwhile did not get a chance to show Sandy Park his skills, but he has been handed the fly half jersey for Friday's game in Galashiels.
"We need to back up that performance against the Wolfhounds by getting it right away from home against Scotland this week," said England Saxons coach Jon Callard. "The endeavour and energy we showed last week at Exeter was first class but not everything was absolutely spot on and we need to improve our accuracy and execution.
"We always planned to make changes over the course of these two games and it means there are more chances for those who've been playing well in the Aviva Premiership and in Europe this season."
ENGLAND SAXONS TEAM TO PLAY SCOTLAND
Friday, February 3rd, 2012
Kick off 7:30pm
15 Nick Abendanon (Bath)
14 Ugo Monye (Harlequins)
13 Jonathan Joseph (London Irish)
12 Billy Twelvetrees (Leicester Tigers)
11 Jonny May (Gloucester)
10 Ryan Lamb (Northampton Saints)
9 Ben Spencer (Saracens)
1 Nick Wood (Gloucester)
2 Chris Brooker (Harlequins)
3 Paul Doran-Jones (Northampton Saints)
4 Ed Slater (Leicester Tigers)
5 George Robson (Harlequins)
6 James Gaskell (Sale Sharks)(capt)
7 Andy Saull (Saracens)
8 Tom Johnson (Exeter)
16 Joe Gray (Harlequins)
17 Rupert Harden (Gloucester)
18 Kearnan Myall (Sale Sharks)
19 David Seymour (Sale Sharks)
20 Paul Hodgson (London Irish)
21 Freddie Burns (Gloucester)
22 Miles Benjamin (Worcester Warriors