Tom Wood captains the side in Salta, and there are three more Saints on the bench, with Paul Doran Jones, Courtney Lawes and Ben Foden all selected by England head coach Stuart Lancaster. Future Saint Alex Corbisiero was not considered due to his call-up to the British and Irish Lions touring party.
Saturday's game kicks off at 8:10pm UK time, and Lancaster is expecting a tough clash against the Pumas.
"Facing Argentina in front of their home crowd in Salta will be a tough challenge," he said. "But we are looking forward to it and I am sure the players will give their all for the shirt.
"It is great to have so many young players pushing through and to be able to give them their opportunities on this tour. It is a young England side but one with a great deal of ability and self-belief and it will be great to see how they perform in the intensity of test match rugby."
Saturday's game is being shown live on BBC2, with coverage starting at 7:30pm.
ENGLAND TEAM TO PLAY ARGENTINA
Saturday, June 8th, 2013
Kick off 8:10pm BST
15 Mike BROWN (Harlequins)
14 Christian WADE (London Wasps)
13 Jonathan JOSEPH (London Irish)
12 Billy TWELVETREES (Gloucester)
11 David STRETTLE (Saracens)
10 Freddie BURNS (Gloucester)
9 Lee DICKSON (Northampton Saints)
1 Joe MARLER (Harlequins)
2 Rob WEBBER (Bath)
3 David WILSON (Bath)
4 Joe LAUNCHBURY (London Wasps)
5 Dave ATTWOOD (Bath)
6 Tom WOOD (Northampton Saints)(capt)
7 Matt KVESIC (Worcester Warriors)
8 Ben MORGAN (Gloucester)
16 David PAICE (London Irish)
17 Paul DORAN JONES (Northampton Saints)
18 Henry THOMAS (Sale Sharks)
19 Courtney LAWES (Northampton Saints)
20 Billy VUNIPOLA (London Wasps)
21 Richard WIGGLESWORTH (Saracens)
22 Kyle EASTMOND (Bath)
23 Ben FODEN (Northampton Saints)