The prop, who has played 21 times for the Saints since making the summer switch from Gloucester, is making his first appearance for the Saxons since 2010.
Doran Jones starts on the tight-head side of the scrum and has been identified by coach Jon Callard as being one of the leaders of the team that takes on the Irish Wolfhounds in Exeter
"Paul Doran-Jones runs the scrum, George Robson the lineout, Freddie Burns and Ben Spencer will control the tempo, and Delon Armitage brings his vision and authority at full back," Callard says. "We want to see the players express themselves and at the same time develop the streak of pragmatism you need to win big games.
"We've seen in Europe the strength of Irish rugby at the moment but the challenge motivates and excites us. But it is a new era for us, there's a lot of youth and energy in this squad and we'll go into the game with a 'no fear' attitude."
Doran Jones's clubmate Ryan Lamb starts on the bench. The game is being shown live on Sky Sports 1/HD1 straight after the Saints' LV= Cup match at Bath.
ENGLAND SAXONS TEAM TO PLAY IRELAND
Saturday, January 28th, 2012
Kick off 5:00pm
15 Delon Armitage (London Irish)
14 Ugo Monye (Harlequins)
13 Matt Hopper (Harlequins)
12 Billy Twelvetrees (Leicester Tigers)
11 Matt Banahan (Bath)
10 Freddie Burns (Gloucester)
9 Ben Spencer (Saracens)
1 Matt Mullan (Worcester Warriors)
2 Joe Gray (Harlequins)
3 Paul Doran Jones (Northampton Saints)
4 Matt Garvey (London Irish)
5 George Robson (Harlequins)
6 James Gaskell (Sale Sharks)(capt)
7 Andy Saull (Saracens)
8 Thomas Waldrom (Leicester Tigers)
16 Chris Brooker (Harlequins)
17 Rupert Harden (Gloucester)
18 Kearnan Myall (Sale Sharks)
19 Tom Johnson (Exeter Chiefs)
20 Paul Hodgson (London Irish)
21 Ryan Lamb (Northampton Saints)
22 Jonny May (Gloucester)