The remaining pair from Franklin’s Gardens are also among the forwards, Kieran Brookes starting at tight-head and Alex Corbisiero among the replacements as the hosts’ Rugby World Cup preparations begin.
After an outstanding 2014/15 in black, green and gold, Clark will get his chance on the international stage as one of three debutants – Henry Slade and Sam Burgess forming a brand new midfield partnership.
Wood meanwhile captains England at home for the first time, having also filled the role on the 2013 Tour of Argentina.
Head Coach Stuart Lancaster said: “We are really excited to play our first QBE International at Twickenham and to put into practice some what we have been working on for the last six weeks.
“The lads are itching to get out and play a match and these games give us a chance to look at a wide range of players and combinations before we narrow down our selection further.
“Tom is one of several leaders in the squad and he captained the team well in Argentina when Chris Robshaw was rested so this is an ideal opportunity to take the armband at Twickenham against what will be a quality French team.”
The match will be shown live on Sky Sports 1 HD, with coverage from 7:15pm.
ENGLAND TEAM TO PLAY FRANCE
Saturday, August 15th, 2015
Kick off 8pm
15 Alex Goode (Saracens)
14 Anthony Watson (Bath)
13 Henry Slade (Exeter Chiefs)
12 Sam Burgess (Bath)
11 Jonny May (Gloucester)
10 Owen Farrell (Saracens)
9 Richard Wigglesworth (Saracens)
1 Mako Vunipola (Saracens)
2 Rob Webber (Bath)
3 Kieran Brookes (Northampton Saints)
5 Geoff Parling (Exeter Chiefs)
6 Tom Wood (Northampton Saints)(capt)
7 Calum Clark (Northampton Saints)
16 Luke Cowan-Dickie (Exeter Chiefs)
17 Alex Corbisiero (Northampton Saints)
18 David Wilson (Bath)
19 Dave Attwood (Bath)
20 James Haskell (Wasps)
21 Danny Care (Harlequins)
22 Danny Cipriani (Sale Sharks)
23 Billy Twelvetrees (Gloucester)