Wales are currently unbeaten in this season's tournament, but England head to Colwyn Bay with a better points difference and a win for Rob Hunter's team will mean that the Six Nations trophy will head to the east side of the River Severn.
All four of the Saints who helped England to a comprehensive win over Italy at Franklin's Gardens last weekend have been named in the match squad, with Danny Hobbs-Awoyemi, Danny Herriott, Alex Day and Tom Stephenson starting the game on the replacements' bench.
Head coach Hunter is under no illusions as to the challenge ahead of his team.
"It'll be a tough game, but a big game in front of a sold-out crowd," he commented. "Wales have performed very well in this competition and they've been quite consistent with their selection - we'll approach this one as we would any other, we want a good performance from the guys."
Friday's game is being shown live on S4C (Sky channel 134, Virgin Media channel 167).
ENGLAND UNDER-20 TEAM TO PLAY WALES
Parc Eirias, Colwyn Bay
Friday, March 15th, 2013
Kick off 7:35pm
15 Ollie Devoto (Bath)
14 Anthony Watson (London Irish)
13 Mark Jennings (Sale Sharks)
12 Sam Hill (Exeter Chiefs)
11 Jack Nowell (Exeter Chiefs)
10 Henry Slade (Exeter Chiefs)
9 Callum Braley (Bristol)
1 Luke Cowan-Dickie (Exeter Chiefs)
2 Nathan Morris (London Wasps)
3 Kyle Sinckler (Harlequins)
4 Elliott Stooke (Gloucester)
5 Dominic Barrow (Leeds Carnegie)
6 Harry Wells (Leicester Tigers)
7 David Sisi (London Irish)
8 Jack Clifford (Harlequins)
16 Max Crumpton (Saracens)
17 Danny Hobbs-Awoyemi (Northampton Saints)
18 Danny Herriott (Northampton Saints)
19 Tom Jubb (Saracens)
20 Gus Jones (London Wasps)
21 Alex Day (Northampton Saints)
22 Tom Stephenson (Northampton Saints)
23 Ben Howard (Worcester Warriors)