Both Lawes and Wood appear in their second World Cups, having played in New Zealand in 2011, while Brookes is in line for a tournament debut should he come off the bench at Twickenham.
Head coach Stuart Lancaster has named an unchanged starting team from the one that beat Ireland in the final warm-up game and says the team are raring to go.
"The squad is massively excited to start the World Cup. Everyone has worked incredibly hard over the last three months and we are ready.
"Friday will be a great occasion for the whole squad and for the country. We are in a unique position to be playing in a World Cup on home soil and to have the support of a nation behind the team. That support will be a massive factor and we don't underestimate its importance.”
The game is an 8pm kick off and is live on ITV1 and ITV1 HD.
ENGLAND TEAM TO PLAY FIJI
Rugby World Cup 2015
Friday, September 18th, 2015
Kick off 8pm
15 Mike Brown (Harlequins, 39 caps)
14 Anthony Watson (Bath Rugby, 11 caps)
13 Jonathan Joseph (Bath Rugby, 13 caps)
12 Brad Barritt (Saracens, 23 caps)
11 Jonny May (Gloucester Rugby, 16 caps)
10 George Ford (Bath Rugby, 13 caps)
9 Ben Youngs (Leicester Tigers, 49 caps)
1 Joe Marler (Harlequins, 33 caps)
2 Tom Youngs (Leicester Tigers, 24 caps)
3 Dan Cole (Leicester Tigers, 52 caps)
4 Geoff Parling (Exeter Chiefs, 25 caps)
5 Courtney Lawes (Northampton Saints, 40 caps)
6 Tom Wood (Northampton Saints, 38 caps)
8 Ben Morgan (Gloucester Rugby, 29 caps)
16 Rob Webber (Bath Rugby, 13 caps)
17 Mako Vunipola (Saracens, 23 caps)
18 Kieran Brookes (Northampton Saints, 12 caps)
20 Billy Vunipola (Saracens, 19 caps)
21 Richard Wigglesworth (Saracens, 23 caps)
22 Owen Farrell (Saracens, 31 caps)
23 Sam Burgess (Bath Rugby, 2 caps)
Franklin’s Gardens is the only place in Northampton with an outdoor cinema screen for some of the tournament’s biggest matches, including England’s clashes with Wales (Sept 26th) and Australia (Oct 3rd), as well as all four quarter finals. To book your tickets for these special events head to www.northamptonsaints.co.uk/buytickets