Head coach Stuart Lancaster has named an unchanged starting 15, meaning Luther Burrell, Dylan Hartley, Courtney Lawes and Tom Wood all retain their starting places with Lee Dickson as one of the replacements.
Lancaster has made just the one change to the match day 23 which beat Wales last Sunday to secure a first Triple Crown in 11 years, Manu Tuilagi replacing Alex Goode on the bench.
England are still in the running to add the Six Nations title to the Triple Crown, but need to both beat Italy and hope that France can do them a favour against Ireland in Paris later in the day.
Meanwhile George North has retained his place on the wing for Wales's final match against Scotland.
All of this weekend's Six Nations action is on Saturday afternoon and live on the BBC.
ENGLAND TEAM TO PLAY ITALY
Saturday, March 15th, 2014
Kick off 12:30pm UK time
15 Mike Brown (Harlequins)
14 Jack Nowell (Exeter Chiefs)
13 Luther Burrell (Northampton Saints)
12 Billy Twelvetrees (Gloucester)
11 Jonny May (Gloucester)
10 Owen Farrell (Saracens)
9 Danny Care (Harlequins)
1 Joe Marler (Harlequins)
2 Dylan Hartley (Northampton Saints)
3 David Wilson (Bath)
4 Joe Launchbury (London Wasps)
5 Courtney Lawes (Northampton Saints)
6 Tom Wood (Northampton Saints)
7 Chris Robshaw (Harlequins)(capt)
8 Ben Morgan (Gloucester)
16 Tom Youngs (Leicester Tigers)
17 Mako Vunipola (Saracens)
18 Henry Thomas (Sale Sharks)
19 Dave Attwood (Bath)
20 Tom Johnson (Exeter Chiefs)
21 Lee Dickson (Northampton Saints)
22 George Ford (Bath)
23 Manusamoa Tuilagi (Leicester Tigers)