This is the seventh year that Harlequins have chosen to move their Christmas fixture to the home of England rugby, and the first time that the Saints have played in the Big Game.
Attendances for Quins' Big Game have averaged out at over 70,000 during the past seven years, with the festive clashes becoming a family day out which provides more than just a rugby match.
Off-field entertainment in previous years has included stunning pyrotechnic displays, unique match ball deliveries and entertainment performances from Olly Murs, Lawson, Killer Queen, Pineapple Dance Group, The Rat Pack and X-Factor Winners Matt Cardle and Sam Bailey.
Tickets for Big Game 7 will go on sale on Wednesday, July 16th at 9:00am. Full information will be announced then!