Back row forwards Calum Clark and Phil Dowson, along with scrum-half Lee Dickson, are amongst the 13 changes made by interim head coach Stuart Lancaster -nine of whom are uncapped.
The Saints trio fall under this category, though all have previous representative experience - both Dowson and Dickson with the Saxons and Clark as a former England Under-20 captain.
No other club has more than the Saints' eight selections and with the simultaneous announcement of the Saxons EPS squad, the total number Saints representatives rises to 10, Paul Doran Jones and Ryan Lamb a part of the 'A' team group.
England's Six Nations defence begins on February 4th with their Calcutta Cup clash against Scotland at Murrayfield.
ENGLAND ELITE PLAYER SQUAD
2012 SIX NATIONS
FORWARDS: Mouritz Botha (Saracens), CALUM CLARK (Northampton Saints), Alex Corbisiero (London Irish), Dan Cole (Leicester Tigers), Tom Croft (Leicester Tigers), Louis Deacon (Leicester Tigers), PHIL DOWSON (Northampton Saints), DYLAN HARTLEY (Northampton Saints), COURTNEY LAWES (Northampton Saints), Joe Marler (Harlequins), Lee Mears (Bath Rugby), Ben Morgan (Scarlets), Tom Palmer (Stade Francais), Chris Robshaw (Harlequins), Matt Stevens (Saracens), Rob Webber (London Wasps), David Wilson (Bath Rugby), TOM WOOD (Northampton Saints)
BACKS: CHRIS ASHTON (Northampton Saints), Brad Barritt (Saracens), Mike Brown (Harlequins), LEE DICKSON (Northampton Saints), Owen Farrell (Saracens), Toby Flood (Leicester Tigers),BEN FODEN (Northampton Saints), Charlie Hodgson (Saracens), Joe Simpson (London Wasps), Charlie Sharples (Gloucester Rugby), David Strettle (Saracens), Manusamoa Tuilagi (Leicester Tigers), Jordan Turner-Hall (Harlequins), Ben Youngs (Leicester Tigers)