In the Championship Moseley will be looking to build on last weekend's stunning comeback win over Bristol by downing fourth-placed Leeds Carnegie at Billesley Common.
They include two Saints Senior Academy players in their starting line-up, scrum-half Ryan Glynn and prop Tom Warren, with another Senior Academy prop Danny Herriott and first team forward Sam Dickinson both on the replacements' bench.
Meanwhile, at Volac Park, Cambridge will be looking to shrug off last week's Tynedale reverse by defeating another club from the north, Wharfedale.
Senior Academy forward Darrell Dyer wears the number seven shirt for this game, with fellow Academy up-and-comers Teimana Harrison and Will Hooley both starting the game on the bench.
