The pair are two of nine changes to the team which narrowly lost to South Africa, with England looking to rebound in style at George's Outeniqua Park.
Fly half Sam Olver, who converted both of England's tries in Friday's defeat in Cape Town, has been named on the bench.
“The players have responded well to the loss against the South Africans," said head coach John Fletcher. "They have trained well over the past few days and we will better for the hit-out last Friday.
“Wales had an excellent victory and performance against a good French team and we know that we will have to play at our best to be competitive. Our players are hurting after the narrow defeat to South Africa and I am expecting a response from the squad against Wales.”
Score updates from South Africa will be posted regularly on the RFU's official Twitter feed.
ENGLAND U18 TEAM TO PLAY WALES
Outeniqua Park, George, South Africa
Tuesday, August 13th, 2013
Kick off 3:00pm UK time
15 Nathan Earle (Saracens)
14 Josh Skelcey (Northampton Saints)
13 Max Clark (Bath)
12 Rory Jennings (Bath)
11 Tom Fowlie (London Irish)
10 Josh Sharp (Saracens)
9 James Mitchell (Sale Sharks)
1 Luke Chapman (Exeter Chiefs)
2 Jack Walker (Leeds Carnegie)
3 Paul Hill (Leeds Carnegie)
4 Josh Peters (Northampton Saints)
5 Charlie Ewels (Bath)
6 Hayden Stringer (Saracens)
7 Will Owen (Leicester Tigers)
8 James Chisholm (Harlequins)(capt)
16 Cameron Neild (Sale Sharks)
17 Alex Lundberg (London Wasps)
18 Ciaran Parker (Sale Sharks)
19 Tom Ellis (Bath)
20 Lewis Ludlow (Gloucester)
21 Ellis Genge (Bristol)
23 Sam Olver (Northampton Saints)
24 Nick Carpenter (Bristol)