Saints return home to Franklin's Gardens and the Aviva Premiership to take on their newest local rivals Wasps on Saturday 28 October.
Heading back into the Premiership, where they currently occupy third place, Saints will be looking to continue their good home form in the competition in round seven as some of the biggest names in English rugby, including British and Irish Lions and England and Wales stars, go head to head.
Last year's finalists Wasps, who sit 10th in the table, enjoyed a strong start, winning their opening two games, but injuries have since struck and they have struggled to back up that pair. But with key men returning from the physio's table, the Coventry-based side will be looking to turn their form around as they head to the Gardens on 28 October (15:00).
It's a case of old rivals, new derby and tickets start from just £32 (adults) and £14 (under-16s).