North withdrew from the midweek win over the Eastern Kings after picking up a virus, but has been deemed well enough to be selected by Wales coach Warren Gatland to face the Springboks.
North will have fond memories of playing South Africa, having scored the first two of his 18 international tries against them on his debut back in 2010.
Gatland's most eye-catching selection is Matthew Rees, the hooker who only returned to playing in March after treatment for testicular cancer.
Saturday's game in Durban is the first of a two-test series, with live coverage on Sky Sports 1 from 4pm.
WALES TEAM TO PLAY SOUTH AFRICA
Kings Park, Durban
Saturday, June 14th, 2014
Kick off 4:00pm UK time
15 Liam Williams (Scarlets)
14 Alex Cuthbert (Cardiff Blues)
13 Jonathan Davies (Scarlets)
12 Jamie Roberts (Racing Metro)
11 George North (Northampton Saints)
10 Dan Biggar (Ospreys)
9 Mike Phillips (Racing Metro)
1 Gethin Jenkins (Cardiff Blues)
2 Ken Owens (Scarlets)
3 Adam Jones (Ospreys)
4 Luke Charteris (Perpignan)
5 Alun Wyn Jones (Capt) (Ospreys)
6 Dan Lydiate (Racing Metro)
7 Aaron Shingler (Scarlets)
8 Taulupe Faletau (Newport Gwent Dragons)
16 Matthew Rees (Cardiff Blues)
17 Paul James (Bath)
18 Samson Lee (Scarlets)
19 Ian Evans (Ospreys)
20 Josh Turnbull (Scarlets)
21 Gareth Davies (Scarlets)
22 James Hook (Perpignan)
23 Matthew Morgan (Ospreys)