Centre Rotimi Segun and hooker Freddie Davison start the clash at Oxford University's Iffley Road, while front row duo Garth Spencer and Henry Peck, along with fly half Paddy McDuell, are also part of the 23-man group.
The quintet's involvement follows hot on the heels of a raft of Saints-England success.
A quartet of junior Saints won the FIRA/AER European Championship with England Under-18 a week ago - just a fortnight after England Under-20 scooped an unprecedented third straight Six Nations title with help from six of the black, green and gold Academy. Two of those youngsters were also part of a trio who secured a dramatic win for England Under-19 against Ireland earlier this week.
