Both were involved last Wednesday as the Southern Barabarians were comprehensively put away and Dickson also got into the thick of the action during the second Test defeat in Johannesburg this past weekend.
Elswhere in the squad, Ugo Monye (wing), Tom Youngs (hooker) and Jamie Gibson (flanker) all make their first starts of the tour and Karl Dickson, brother of Lee, comes straight into the matchday 22 after Ben Youngs' injury.
Lancaster is determined to use the midweek match as a springboard to avoid a series whitewash when his side meet the Springboks again this Saturday afternoon.
"We have talked today about finishing the tour strongly this week and these players have a great opportunity to do this in the second of the two midweek games," England's head coach commented. "There are still selection decisions to be made for Saturday but the players' focus will be on putting in a strong cohesive team performance and building on on the positives from last week, but also learning the lessons."
ENGLAND SIDE TO FACE SA NORTHERN BARBARIANS
Profert Olen Park, SA
Tuesday, June 19th, 2012
Kick off 6:10pm BST
Live on Sky Sports HD
15 Nick Abendanon (Bath Rugby)
14 Christian Wade (London Wasps)
13 Anthony Allen (Leicester Tigers)
12 Jordan Turner-Hall (Harlequins)
11 Ugo Monye (Harlequins)
10 Charlie Hodgson (Saracens)
9 Lee Dickson (Northampton Saints)
1 Matt Mullan (Worcester Warriors)
2 Tom Youngs (Leicester Tigers)
3 Paul Doran Jones (Northampton Saints)
4 Graham Kitchener (Leicester Tigers)
5 George Robson (Harlequins) (capt)
6 Jamie Gibson (London Irish)
7 Carl Fearns (Bath Rugby)
8 Ben Morgan (Scarlets)
16 Joe Gray (Harlequins)
17 Rupert Harden (Gloucester Rugby)
18 Mouritz Botha (Saracens)
19 James Haskell (Otago Highlanders)
20 Karl Dickson (Harlequins)
21 David Strettle (Saracens)
22 Jonny May (Gloucester Rugby)