Four of the seven tries came from Saintsmen, while Luther Burrell and Stephen Myler made their first senior starts in England colours - the latter kicking three conversions in Montevideo.
First to cross of the Saints' try scoring trio was Ben Foden - the assist coming from fly half and clubmate Myler - and the full back would double his tally after the break. Not before Tom Wood went over in his first game as England captain, however, following up Foden's opener and a treble for number 8 Billy Vunipola.
The black, green and gold contingent - which also included Courtney Lawes and future Saint Alex Corbisiero - weren't done there though, Lee Dickson and Paul Doran Jones joining the action from the bench and the prop rumbling over for his side's seventh and final try on a comfortable afternoon for those in white.
With a pair of Tests to come against Argentina though - the first in Salta next Saturday, June 8th - new skipper Wood was keen not to get carried away with the result, instead looking for increased continuity throughout the 80 minutes.
"It's hard to know what to take from a game where you've won by so many points," Wood told the RFU Podcast. "There were times where we got a bit static and that frustrated us, but it will give us plenty to think about heading into next week's game with Argentina.
"There'll be more of the same in that game, perhaps with a higher intensity and certainly a bit more experience. We'll need to be better than we were today though to compete.
"That said, there are a lot of new faces in this side and I thought they all made a good contribution to the performance today. Moving forward it will be about us gelling further together and getting the selection right for what will be a tough test."