Saints trio Lewis Ludlam, David Ribbans and Alex Mitchell are all involved once more as England round-off their Six Nations campaign with a trip to Dublin on Saturday.
Ludlam makes his fifth straight start in the competition on the blindside flank and is also selected as vice-captain, while club mate Ribbans joins him in the pack at Aviva Stadium.
Alex Mitchell – who caught the eye in his cameo against France – is again among the replacements.
It’s a tall ask against an Ireland side chasing their first Grand Slam since 2018, but head coach Steve Borthwick is hopeful that England can finish their campaign on a high.
"We travel to Dublin to face an Ireland team on Saturday that has the chance to secure a Grand Slam Championship victory at home for the first time" said Borthwick.
"We know that after the bitter disappointment of the display against an exceptional France team last week, we will have to be much improved to meet the challenge of playing the side presently ranked number one in the world.
"However, I have witnessed an England squad determined to make amends for the defeat at Twickenham, and I am confident that the team announced today will once again want to show the sort of resilience and attitude that brought us victory in Wales."
The match, which kicks off at 5.00pm, is being broadcast live on ITV.
England side to face Ireland
15. Freddie Steward
14. Anthony Watson
13. Henry Slade
12. Manu Tuilagi
11. Henry Arundell
10. Owen Farrell (C)
9. Jack van Poortvliet
1. Ellis Genge (VC)
2. Jamie George
3. Kyle Sinckler
4. Maro Itoje
5. David Ribbans
6. Lewis Ludlam (VC)
7. Jack Willis
8. Alex Dombrandt
Replacements
16. Jack Walker
17. Mako Vunipola
18. Dan Cole
19. Nick Isiekwe
20. Ben Curry
21. Alex Mitchell
22. Marcus Smith
23. Joe Marchant
