Dan Lewis, Nico Defeo, George Wacokecoke and Ryan Headington all crossed the whitewash for the Saints, but there were nerves aplenty in the final few minutes as Worcester threatened a dramatic late score.
The Saints youngsters, who were being captained for the first time by Steve Arroyo-Hover, got off to a great start, running in three unanswered tries. But Worcester came back with two scores of their own to pull the deficit back to just three points.
A fourth effort from the visitors eased them clear once again, and while Worcester crossed for a third try the Saints youngsters held on to seal the three-point victory.
With a number of Under-16s making their Junior Saints Academy debuts there was plenty for Academy manager Alan Dickens to be pleased about.
"When we played at tempo we put together some good passages of play to score our tries," he said. "But it was also pleasing to see us get on top in the scrum as well and I thought Simon Uzokwe was excellent at loosehead prop.
"Steve Arroyo-Hover led the team well on his first time out as captain, and the game was an excellent opportunity to see some of the Under-16s in action at a more senior level.
"I would especially like to thank all of the parents and players for their commitment they showed in getting to Worcester for an 11 o'clock kick off. At this level we are very much reliant on family support and it is very much appreciated by all of the Academy staff within the club."