Scores for Danny Herriott and Tom Collins sealed the deal after the break, the Wanderers having seen Matt Williams and Teimana Harrison's efforts cancelled out just before half-time in a forwards dominated battle.
A lovely break and offload from Williams almost sent Tom Collins into the corner early doors and despite a penalty the hosts could only half clear. When the Wanderers hooker got his hands on the ball again, he chose to go himself and Dark Blue defenders couldn't live with a typically explosive burst.
The second score seemed to owe inspiration to the first team's efforts in Newport a night earlier, Will Hooley sending a penalty to the corner and the forwards driving Teimana Harrison over with ease, but the hosts responded in kind.
After their own maul made some 20 metres, Harrison saw yellow for halting its progress and the very next play Oxford had their first try of the evening to take the game back within a score.
The Wanderers remained unscathed for the next nine minutes, but with Oxford staying in the front foot the forwards produced another try for Bob Baker almost immediately after Harrison's return. The scores were again level and remained that way until the break, the Blues unsuccessful with the extras.
It wasn't until the 51st minute that a side took the lead and it was the Wanderers who were on top again, Collins and Noah Cato providing the impetus and Hooley nudging over the three points from straight in front. They were soon on the attack again, though when Collins scooted around the last man the referee's assistant claimed the effort was held up, much to the Wandies winger's disbelief.
Much of the second period was being wasted in the scrum, neither side able to sustain any kind of prolonged dominance at the set piece. The maul however continued to be king and Danny Herriott stretched out a long enough arm to dot down. Sam Olver's conversion opened up a 10-point lead for the second time and Charlie Marr's missed penalty meant that when Tom Collins crossed for the try of the night, that advantage became an insurmountable one.
Scott Armstrong made the telling break up and over halfway and superbly through the hands of Alex Wootton, Collins was under the posts from full back for the would-be bonus score and that was that.
The Wanderers are back in action next Wednesday, October 28th when the RAF come to Franklin's Gardens. Entry is free to all Season Ticket Holders, Associate Members and Bernie's Gang Members.
10mins WAND Try Williams 0-5
21mins WAND Try Harrison 0-10
25mins WAND Yellow Harrison
26mins OX UNI Try 5-10
38mins OX UNI Try Baker 10-10
HALF-TIME OX UNI 10 WANDERERS 10
51mins WAND Pen Hooley 10-13
66mins WAND Try Herriott Con Olver 10-20
68mins OX UNI Miss pen Marr
72mins WAND Try Collins Con Olver 10-27
FULL-TIME OX UNI 10 WANDERERS 27