It is the first time that an England team has whitewashed the Pumas on their own soil, and this series came 32 years after Bill Beaumont skippered his side to a win and a draw.
Indeed, that was the only other time that England have won a test match series in Argentina, and as the hosts kicked themselves to a 12-6 lead the tourists found themselves having to dig deep to continue the momentum generated in Salta the weekend before.
By half-time they were two scores clear, with the pack earning two penalty tries and Freddie Burns adding a try of his own as well as two conversions. After the break it was all England, with Marland Yarde (2), Kyle Eastmond and Rob Webber all going over the whitewash in the 51-26 win.
From a Saints perspective Stephen Myler had the honour of winning his first senior cap, and when the fly half came onto the field it represented the first time that six players from Franklin's Gardens had played for England in the same game.
Lee Dickson was sharpness personified at scrum-half, with Ben Foden, Paul Doran Jones and Courtney Lawes all coming off the bench to make an impact.
England's season may be over, but Alex Corbisiero's campaign is continuing, the loose-head prop helping the British and Irish Lions to a comfortable 47-17 win over New South Wales in Sydney.
Corbisiero, who is moving to Franklin's Gardens later in the summer, is on the bench for Tuesday's game against ACT Brumbies in Canberra. There is positive news about his fellow future clubmate, George North, who took part in Monday's captain's run.
Tuesday's game between the Brumbies and the Lions can be watched live on Sky Sports.