The trio provide a Saints spine in a familiar looking pack, while Hartley is the most experienced man in the squad with 57 caps to his name.
The backline is less tried and tested, Bath flyer Semesa Rokoduguni earning a Test debut following his blistering start to the Aviva Premiership season and Johnny May on the opposite wing.
Kyle Eastmond and Brad Barritt link up in midfield in the absence of Luther Burrell.
Among the replacements, form Saracens lock George Kruis is in line for his international bow, likewise Anthony Watson, who recently made his return from injury.
New Zealand meanwhile, who handed out a clinical 74-6 mauling of the USA last weekend, make 11 changes to the starting XV from Chicago.
That means only Israel Dagg, Sonny Bill Williams, Aaron Cruden and Kieran Read are retained as coach Steve Hansen reverts to one of the most settled sides in International Rugby.
The match, which is being shown live from Twickenham on Sky Sports, is a 2:30pm kick off.
ENGLAND TEAM TO FACE NEW ZEALAND
Saturday, November 8th, 2014
Kick off 2:30pm
15 Mike Brown (Harlequins, 29 caps)
14 Semesa Rokoduguni (Bath Rugby, uncapped)
13 Brad Barritt (Saracens, 18 caps)
12 Kyle Eastmond (Bath Rugby, 4 caps)
11 Jonny May (Gloucester Rugby, 7 caps)
10 Owen Farrell (Saracens, 25 caps)
9 Danny Care (Harlequins, 48 caps)
1 Joe Marler (Harlequins, 22 caps)
2 Dylan Hartley (Northampton Saints, 57 caps)
3 David Wilson (Bath Rugby, 37 caps)
4 Dave Attwood (Bath Rugby, 12 caps)
5 Courtney Lawes (Northampton Saints, 32 caps)
6 Tom Wood (Northampton Saints, 30 caps)
7 Chris Robshaw (Harlequins, 28 caps) (capt)
8 Billy Vunipola (Saracens, 10 caps)
16 Rob Webber (Bath Rugby, 8 caps)
17 Matt Mullan (Wasps, 5 caps)
18 Kieran Brookes (Newcastle Falcons, 2 caps)
19 George Kruis (Saracens, uncapped)
20 Ben Morgan (Gloucester Rugby, 23 caps)
21 Ben Youngs (Leicester Tigers, 38 caps)
22 George Ford (Bath Rugby, 2 caps)
23 Anthony Watson (Bath Rugby, uncapped)
NEW ZEALAND Israel Dagg; Ben Smith, Conrad Smith, Sonny Bill Williams, Julian Savea; Aaron Cruden, Aaron Smith; Kieran Read, Richie McCaw (capt), Jerome Kaino; Sam Whitelock, Brodie Retallick; Owen Franks, Dane Coles, Wyatt Crockett
Replacements: Keven Mealamu, Ben Franks, Charlie Faumuina, Patrick Tuipulotu, Liam Messam, TJ Perenara, Beauden Barrett, Ryan Crotty