Forward power and slick finishing did the damages for the hosts, who produced five different scorers as well as a second-half penalty try. Wanderers fly half Stephen Myler also kicked 15 points.
The Wanderers applied all the early pressure with a string of penalties - one of which Myler kicked - and after powerful work from Luther Burrell, they kept the ball moving and out wide to James Wilson, who dashed over. It was no more than the Wanderers deserved and while Myler groaned with frustration at hitting the conversion wide, it was all but the perfect start.
As the Saints' win at Gloucester showed at the weekend though, momentum can shift at the flick of a switch and when Martin Roberts checked Alex Lewington en route to the try line, referee Martin Fox awarded not only a penalty try, but also a yellow card for the hosts' scrum-half.
Nevertheless, the forward power that had been present for much of the opening quarter remained for the Wanderers and the pack would earn two three-point penalties via the boot of Myler.
With Roberts not yet back on the field, the Wanderers added to their sin bin scoring and this time it was a maximum. Tom May snuck through a gap and tip-toed his way down the touchline from halfway, the centre's score owing as much to a clever supporting line from Noah Cato as his own pace.
The winger would play a more prominent hand in the Wanderers' third, too, scooting through a gap from the back foot and dancing inside defenders despite slipping off his feet. Roberts and Wilson were up in support and Cato's pass was timed well enough to put the scrum-half away.
Things weren't going the visitors' way and while they were enjoying their fair share of both the ball and territory, errant passes and dropped balls were costing them dear.
It was a pattern that repeated at the start of the second half and following a yellow card for hooker Rob Hawkins the visitors failed to clear their lines. A man light in the scrum, the Wanderers made them pay with a penalty try that also brought about the bonus point.
The punishment wouldn't stop there either. Myler turned down a kickable chance at goal and the decision paid dividends to the full, Ethan Waller the man driven over from the resulting lineout.
Hawkins returned and the Wanderers rang the changes but by now they were in full flow. Another lineout maul produced a try for Teimana Harrison and with Hooley's conversion a success, the hosts were bearing down on a half century.
Despite a tring of 5-metre lineouts and penalties it it wouldn't come, and Tigers nicked one back through full back Niall Morris to make the scoreline a little less one-sided. Nevertheless, it was the Wanderers' night and first East Midlands bragging rights of the season belonged to the black, green and gold.
4mins WAND Pen Myler 3-0
9mins WAND Try Wilson 8-0
14mins WAND Yellow Roberts
14mins TIGERS Try Penalty Con Cornwell 8-7
19mins WAND Pen Myler 11-7
22mins WAND Pen Myler 14-7
24mins WAND Try May Con Myler 21-7
30mins WAND Try Roberts 26-7
HALF-TIME WAND 26 TIGERS 7
45mins TIGERS Yellow Hawkins
47mins WAND Try Penalty Con Myler 33-7
54mins WAND Try E Waller Con Myler 40-7
68mins WAND Try Harrison Con Hooley 47-7
73mins TIGERS Try Morris Con Cornwell 47-14
FULL-TIME WANDERERS 47 TIGERS 14