Eight different scorers registered, with Scott Armstrong bagging a double and the opening try coming from a combined forward effort.
From kick off the Wanderers worked their way upfield and with the hosts conceding four penalties in five minutes, a 5-metre scrum somewhat inevitably ended in a penalty try and the simplest of conversions for Stephen Myler.
The Blues were struggling to cope with the Wanderers' directness and power up front and while Jon Hudson took a yellow card for his side's continued infringements, some determined defence meant it wasn't until eight minutes into the sin bin that Tom May cut through on the end of some slick interplay with Myler.
It was a bruising encounter and one that the Wanderers were certainly on top in, the forwards bullying their way close to the line in a move that was finished off by Stu Commins - before Samu Manoa got in on the act with the would be bonus score in the same corner.
The Wanderers side that emerged for the second half had a far more youthful look about it, but it was a combination of three of the starters who carved out the fifth, Myler putting a cross-kick right down Paul Diggin's throat and the winger had no trouble releasing Armstrong in the corner. The conversions weren't getting any easier for Myler but he remained immaculate from the tee and the Wanderers were 35 clear.
The next try did come for one of the Academy replacements and it was back to brute force as Sam Farmer tagged onto the back of a maul that rumbled over. Oxford would enjoy a spell of pressure of their own but with a stubborn Wanderers defence keen to keep a clean sheet, the next score was a seventh for the visitors, Jamie Elliott tearing through the Blues' backline and sending Armstrong - who tracked the move well again - under the posts for his second.
Alex Day followed Armstrong's lead five minutes later with a quick tap penalty to crack the half century and Tom Stephenson produced a typically powerful finish from 25 metres out to extend the lead further. It was left to Greig Tonks to round off the scoring with another piercing line break for the Wanderers and Glyn Hughes converted a third try on his return from injury.
Having beaten Oxford's Varsity opponents Cambridge in their first outing of the season, it completed a Blue double for the Wanderers and left them in good shape for their top of the table Aviva 'A' League clash with Sale next Monday night.
6mins WAND Try Penalty Con Myler 0-7
16mins OXFORD Yellow Hudson
23mins WAND Try May Con 0-14
36mins WAND Try Commins Con Myler 0-21
39mins WAND Try Manoa Con Myler 0-28
HALF-TIME OXFORD UNI 0 WANDERERS 28
51mins WAND Try Armstrong Con Myler 0-35
59mins WAND Try Farmer 0-40
66mins WAND Try Armstrong Con Tonks 0-47
73mins WAND Try A Day Con Hughes 0-54
76mins WAND Try Stephenson Con Hughes 0-61
80mins WAND Try Tonks Con Hughes 0-68
FULL-TIME OXFORD UNI 0 WANDERERS 68