Tom Wood is among the replacements in Manchester this Saturday, England head coach Stuart Lancaster fielding a youthful looking side for England's final game of the 2015 Rugby World Cup.
The biggest shake up comes in the backs, where Alex Goode, Henry Slade, Jack Nowell, George Ford and Danny Care all start.
Up front, meanwhile, Mak Vunipola, James Haskell and Nick Easter all make their first starts of the tournament as the City of Manchester Stadium welcomes rugby union for the first time.
Lancaster is hoping England can go out on a high.
“This is an opportunity for us to finish the tournament with a strong performance against Uruguay and a chance for the likes of young players such as Jack Nowell and Henry Slade to play in a World Cup," he commented.
“We owe it to ourselves and the supporters who have been brilliant throughout. This is an important game for rugby in the north of England and we want to give those people who have been looking forward to this game something to cheer about.”
The game is an 8pm kick off once again, live on ITV.
ENGLAND TEAM TO PLAY URUGUAY
Rugby World Cup 2015
City of Manchester Stadium
Saturday, October 10th, 2015
Kick off 8pm
15 Alex Goode (Saracens, 18 caps)
14 Anthony Watson (Bath Rugby, 14 caps)
13 Henry Slade (Exeter Chiefs, 1 cap)
12 Owen Farrell (Saracens, 34 caps)
11 Jack Nowell (Exeter Chiefs, 9 caps)
10 George Ford (Bath Rugby, 16 caps)
9 Danny Care (Harlequins, 52 caps)
1 Mako Vunipola (Saracens, 26 caps)
2 Tom Youngs (Leicester Tigers, 27 caps)
3 Dan Cole (Leicester Tigers, 55 caps)
4 Joe Launchbury (Wasps, 27 caps)
5 Geoff Parling (Exeter Chiefs, 28 caps)
6 James Haskell (Wasps, 61 caps)
7 Chris Robshaw (capt)(Harlequins, 42 caps)
8 Nick Easter (Harlequins, 53 caps)
16 Jamie George (Saracens, 2 caps)
17 Joe Marler (Harlequins, 36 caps)
18 David Wilson (Bath Rugby, 43 caps )
19 George Kruis (Saracens, 9 caps)
20 Tom Wood (Northampton Saints, 41 caps)
21 Richard Wigglesworth (Saracens, 26 caps)
22 Jonathan Joseph (Bath Rugby, 15 caps)
23 Mike Brown (Harlequins, 42 caps)